About LVPM

Laboratory of Vascular Physiology and Medicine

‘Laboratory of Vascular Physiology & Medicine’ (LVPM) is a specialized research laboratory established in the Department of Physiology under Faculty of Medicine, BLDE (Deemed to be University). This laboratory is working extensively on Experimental Physiology and Clinical Physiology/Medicine research. The Laboratory is formally inaugurated on 15th.December 2015 by Professor Robert G.Carroll (East Carolina University, NC, USA) & Professor Dewan S.A.Majid (Tulane University, New Orleans, USA).

Research Focus: Department of Physiology has established “Laboratory of Vascular Physiology & Medicine” under the supervision of Professor Kusal Das. This BLDE (Deemed to be University) Laboratory of Vascular Physiology is working extensively on both human and animal model to explore and understand physiological basis of clinical acumen to vascular integrity. It has a specialized ‘ELECTROPHYSIOLOGY UNIT”, ‘MOLECULAR BIOLOGY UNIT’ and ‘CLINICAL PHYSIOLOGY/MEDICINE UNIT’ The focus of the BLDE (Deemed to be University) Laboratory of Vascular Physiology is studying vascular function/dysfunction in healthy and diseased states, with particular emphasis on chronic cardiovascular diseases, diabetes mellitus.

BLDE University Vascular Lab

“Electrophysiology Unit” of “Laboratory of Vascular Physiology & Medicine”

BLDE University Vascular Lab

“Electrophysiology Unit” of “Molecular Biology Unit of Laboratory of Vascular Physiology and Medicine”

Additionally, vascular responses to exercise and diet are studied and influences of Yoga and lifestyle intervention on vascular health. A variety of techniques are utilized to examine macro- and microvascular function as well as arterial stiffness in humans and animal models. The BLDE (Deemed to be University) Laboratory of Vascular Physiology also devout itself to carry out different research projects on environmental health, cardiovascular health, respiratory health to functional modulation in different exercise-induced interventional models with their molecular signaling pathways for both human and animal. The BLDE (Deemed to be University) Laboratory of Vascular Physiology takes care of critical experimental protocol on rats and mice where cardiovascular, vascular, respiratory and neurological different parameters can be analyzed by both noninvasive and invasive conditions. BLDE (Deemed to be University) Laboratory of Vascular Physiology is also capable to evaluate various cardiovascular histological analysis with the help of specialized software.

The overall mission of the Laboratory of Vascular Physiology & Medicine Lab is to determine the mechanisms contributes to the development of vascular dysfunction with aging, Metabolic syndrome, diabetes, hypertension etc. Our lab uses integrative experimental approaches to assess vascular function of peripheral arteries, stiffness and hemodynamics of the arteries of human.

Objectives: We have focused interest in translating basic science findings with experimental models to clinically relevant treatments in humans and testing the efficacy of various pharmacological and lifestyle interventions in humans at high risk for developing cardiovascular diseases.

Vision & Mission: The Laboratory comprises of the faculty members and research scholars who works together in either experimental rodent models or clinical models which primarily focused on cardiovascular problems including hypertension or hypoxia and respiratory diseases. The Laboratory of Vascular Physiology & Medicine is strategically working with its experimental physiologists and clinicians to discover or identify the causes and therapy of vascular diseases including stroke.

Research Works at LVPM: The LVPM has a ‘Clinical Physiology/Medicine Unit’ and an ‘Electrophysiology Unit’. Electrophysiology Unit evaluates rats / mice ECG, blood pressure, baroreflex sensitivities (BRS).

BLDE University Vascular Lab

MoU signed by Prof.Luis Gabriel Navar and Prof.M.S.Biradar for 1st official collaboration between the universities. Prof.Kusal Das and Prof.DSA Majid are the Principal collaborators for 3 yrs project. The work will be done under the care of Prof.Das at Laboratory of Vascular Physiology & Medicine, BLDE (Deemed to be University), India and Prof.Dewan S.A.Majid of Hypertension and Renal Centre of Excellence, Tulane University School of Medicine, USA. The Project is entitled “Hypoxia, metal exposure and cell signaling pathways: Evaluation of vascular integrity with renal functions in male albino rats supplemented with ascorbate and calcium channel blocker”

Besides HRV parameters besides EEG and other neurological observations. The laboratory takes care of critical experimental protocol on rats and mice where cardiovascular, vascular, respiratory and neurological different parameters can be analyzed by both noninvasive and invasive conditions. LVSM has both invasive and noninvasive rats/mice blood pressure recording transducers and further going to procure radio telemetry devices. A variety of techniques are utilized to examine macro- and microvascular function as well as arterial stiffness in humans and animal models. Both the Clinical Physiology/Medicine & Electrophysiology Unit also devout itself to carry out different research projects on environmental health, cardiovascular health, respiratory health to functional modulation in different exercise-induced interventional models with their molecular signaling pathways for both human and animal. LVPM also supports biochemical and basic molecular biology experiments and vascular histopathology which critically analyze arterial wall thickness or lumen diameter in experimental animals. The laboratory also devout itself to carry out different research projects on environmental health, cardiovascular health, respiratory health to functional modulation in different exercise-induced interventional models like Yoga and lifestyle modulation along with their molecular signaling pathways. Stroke Model: Translational stroke research is a challenging task that needs long term teamwork of the stroke research community Treatment options to date are very limited. To meet the need for novel therapeutic approaches, highly reproducible stroke models with excellent outcome are essential for obtaining useful data from preclinical stroke trials as well as for improving inter-lab comparability. Experimental stroke research frequently employs rodent models of focal cerebral ischemia. Most researchers use permanent or transient occlusion of the middle cerebral artery (MCA) in mice or rats. Proximal occlusion of the middle cerebral artery (MCA) via the intraluminal suture technique (so-called filament or suture model) is probably the most frequently used model in experimental stroke research. The intraluminal MCAO model offers the advantage of inducing reproducible transient or permanent ischemia of the MCA territory in a relatively non-invasive manner. Intraluminal approaches interrupt the blood flow of the entire territory of this artery. Laboratory of Vascular Physiology & Medicine has established the MCAO technique to induce cerebral ischemia and stroke on rats. The researchers are trained under the supervision of Dr.Sikha Saha, Leeds Institute of Cardiovascular & Metabolic Medicine, University of Leeds. This will further improve to understand focal ischemia/stroke in human and definitely helps to fight against stroke.